Matching-adjusted comparisons demonstrate better clinical outcomes with SC peginterferon beta-1a every two weeks than with SC interferon beta-1a three times per week
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چکیده
منابع مشابه
COMPARE: Pharmacokinetic profiles of subcutaneous peginterferon beta‐1a and subcutaneous interferon beta‐1a over 2 weeks in healthy subjects
AIM Subcutaneous (s.c.) peginterferon beta-1a injected once every 2 weeks and s.c. interferon beta-1a injected three times per week (Rebif®) have demonstrated efficacy in relapsing-remitting multiple sclerosis, but direct comparisons of pharmacological activity and tolerability between the two products are lacking. COMPARE was an open label, crossover, pharmacokinetic (PK) study evaluating drug...
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IL-4: Interleukin 4 IFN-b: Interferon beta IFN-b1a: Interferon beta-1a MS: Multiple sclerosis SSc: Systemic sclerosis Th2: T helper 2 INTRODUCTION Interferon beta-1a (IFN-b1a) is a cytokine therapy used in the treatment of relapsing-remitting multiple sclerosis. The most common adverse injection site reactions include local erythema, pain, and induration. Other less frequently encountered react...
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متن کاملHalo nevi associated with interferon beta-1a therapy.
The interferons are a group of more than 20 glycoproteins produced by numerous body cells in response to the presence of viruses, double-stranded RNA, polypeptides, or bacterial products. All of them share the ability to inhibit viral replication and cell proliferation, and to regulate and modulate immune cells. From an immunologic point of view, interferons increase the expression of class I o...
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ژورنال
عنوان ژورنال: Multiple Sclerosis and Related Disorders
سال: 2018
ISSN: 2211-0348
DOI: 10.1016/j.msard.2018.02.021